A possible relation between dietary zinc and cAMP in the regulation of tumour cell proliferation in the rat

Skeef, N.S. and Duncan, J.R. (1988) A possible relation between dietary zinc and cAMP in the regulation of tumour cell proliferation in the rat. British Journal of Nutrition, 59 (3). pp. 437-442. ISSN 0007-1145

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Official URL: http://dx.doi.org/10.1079/BJN19880052

Abstract

The possibility of an effect of zinc on the rate of tumour cell division, mediated through a regulation of cellular cAMP concentration, was investigated in the present study in rats. Dietary Zn deficiency (< 1·5 mg Zn/kg) but not Zn excess (500 mg Zn/kg) resulted in an increased cAMP concentration in transplanted hepatoma cells. Neither treatment had any effect on the cAMP concentration in regenerating liver or normal resting liver. Both the deficient and excess Zn diets resulted in a small reduction in tumour growth (not statistically significant). The results seem to indicate that the relation investigated in the present study does not apply in the cell line used.

Item Type:Article
Uncontrolled Keywords:animal experiment; cancer; diet; female; liver cancer; nonhuman; priority journal; rat; animal; body weight; cell division; zinc; cyclic AMP; cAMP; liver neoplasms, experimental; liver regeneration; rats; inbred strains; support, Non-U.S. Gov't; cyclic AMP, 60-92-4; zinc sulfate, 7733-02-0; zinc, 7440-66-6; Cyclic AMP, 60-92-4; Zinc, 7440-66-6
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Science > Biochemistry, Microbiology & Biotechnology
ID Code:1026
Deposited By:INVALID USER
Deposited On:21 Jul 2008
Last Modified:06 Jan 2012 16:19
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