Study of the formation of artifacts following Dichloromethane reaction with some nitrogenous drugs

Mohammadi, A. and Amini, M. and Hamedani, M.P. and Torkabadi, H.H. and Walker, R.B. (2008) Study of the formation of artifacts following Dichloromethane reaction with some nitrogenous drugs. Asian Journal of Chemistry, 20 (7). pp. 5573-5580. ISSN 0970-7077

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Abstract

In this work, the quaternization reaction of some nitrogenous drugs in dichloromethane under stress condition and room temperature at different times are studied. Under these conditions, drug-chloromethochloride adducts or artifacts were found to be formed for clozapine, ofloxacin and olanzapine. The structures of the resultant adducts were elucidated using 1H NMR spectroscopy. In addition, the amount of intact drug was determined using in-house validated HPLC methods with UV detection.

Item Type:Article
Additional Information:Prof R B Walker is Dean of the Faculty of Pharmacy at Rhodes University, South Africa.
Uncontrolled Keywords:Adducts; Dichloromethane; Clozapine; Ofloxacin; Olanzapine; Chloromethochloride
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:1131
Deposited By: Mrs Eileen Shepherd
Deposited On:30 Sep 2008
Last Modified:06 Jan 2012 16:19
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