Synthesis of molecularly imprinted polymer for selective solid-phase extraction of Salbutamol from urine samples

Mohammadi, A. and Alizadeh, T. and Dinarvand, R. and Ganjali, M.R. and Walker, R.B. (2009) Synthesis of molecularly imprinted polymer for selective solid-phase extraction of Salbutamol from urine samples. Asian Journal of Chemistry, 21 (4). pp. 2875-2880. ISSN 0970-7077

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Abstract

A highly selective methacrylic based molecularly imprinted polymer (MIP) was synthesized and applied for the separation and the pre-concentration of salbutamol in urine samples. Spectrophotometric determination of salbutamol was achieved using 2,6-dichloroquinone chlorimide as colorimetric reagent. The detection limit of the method was ca. 13 ng/mL in urine after pre-concentration of the samples by MIP-SPE andanalysis with an optimized and sensitive spectrophotometric method. The linear dynamic range for salbutamol determination in urine was 0.04-0.75 μg mL-1. The recovery for the affinity based solid-phase extraction (SPE) with the MIP was more than 96 %.

Item Type:Article
Uncontrolled Keywords:Salbutamol, 2,6-Dichloroquinone chlorimide, Molecularly imprinted polymer, Solid-phase extraction
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:1285
Deposited By: Prof Rod Walker
Deposited On:03 Feb 2009
Last Modified:06 Jan 2012 16:20
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