The TPR2B domain of the Hsp70/Hsp90 organizing protein (Hop) may contribute towards its dimerization

Longshaw, V.M. and Stephens, L.L. and Daniel, S. and Blatch, G.L. (2009) The TPR2B domain of the Hsp70/Hsp90 organizing protein (Hop) may contribute towards its dimerization. Protein and Peptide Letters, 16 (4). pp. 402-407. ISSN 0929-8665

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Abstract

The role of the TPR2B domain of Hop is as yet unknown. We have shown here by site directed mutagenesis and size exclusion chromatography for the first time that the TPR1 and TPR2B domains of Hop independently dimerized, and that the dimerization of TPR2B was not dependent on its predicted two-carboxylate clamp residues. Furthermore, our data indicated that the dimerization of Hop and its domains was not disrupted in the presence of Hsp70 and Hsp90 peptides.

Item Type:Article
Uncontrolled Keywords:Hop, dimerization, tetratricopeptide repeat domain, TPR; TETRATRICOPEPTIDE REPEAT PROTEINS; CO-CHAPERONE HOP; HSP90; BINDING; HSP70; COMPLEXES; MOTIF; RECOGNITION; PHOSPHATASE; MUTATION
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Science > Biochemistry, Microbiology & Biotechnology
ID Code:1376
Deposited By: Mrs Eileen Shepherd
Deposited On:25 May 2009
Last Modified:06 Jan 2012 16:20
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