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Longshaw, V.M. and Stephens, L.L. and Daniel, S. and Blatch, G.L. (2009) The TPR2B domain of the Hsp70/Hsp90 organizing protein (Hop) may contribute towards its dimerization. Protein and Peptide Letters, 16 (4). pp. 402-407. ISSN 0929-8665
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blatch_TPR2B_domain_of_the_Hsp70.pdf 152Kb |
Official URL: http://www.bentham.org/ppl/contabs/ppl16-4.htm#9
Abstract
The role of the TPR2B domain of Hop is as yet unknown. We have shown here by site directed mutagenesis and size exclusion chromatography for the first time that the TPR1 and TPR2B domains of Hop independently dimerized, and that the dimerization of TPR2B was not dependent on its predicted two-carboxylate clamp residues. Furthermore, our data indicated that the dimerization of Hop and its domains was not disrupted in the presence of Hsp70 and Hsp90 peptides.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Hop, dimerization, tetratricopeptide repeat domain, TPR; TETRATRICOPEPTIDE REPEAT PROTEINS; CO-CHAPERONE HOP; HSP90; BINDING; HSP70; COMPLEXES; MOTIF; RECOGNITION; PHOSPHATASE; MUTATION |
| Subjects: | Y Unknown > Subjects to be assigned |
| Divisions: | Faculty > Faculty of Science > Biochemistry, Microbiology & Biotechnology |
| ID Code: | 1376 |
| Deposited By: | Mrs Eileen Shepherd |
| Deposited On: | 25 May 2009 |
| Last Modified: | 06 Jan 2012 16:20 |
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