Health, human rights, and the conduct of clinical research within oppressed populations

Mills, E.J. and Singh, S. (2007) Health, human rights, and the conduct of clinical research within oppressed populations. Globalization and Health , 3 . ISSN 1744-8603

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Official URL: http://dx.doi.org/10.1186/1744-8603-3-10

Abstract

Background Clinical trials evaluating interventions for infectious diseases require enrolling participants that are vulnerable to infection. As clinical trials are conducted in increasingly vulnerable populations, issues of protection of these populations become challenging. In settings where populations are forseeably oppressed, the conduct of research requires considerations that go beyond common ethical concerns and into issues of international human rights law. Discussion Using examples of HIV prevention trials in Thailand, hepatitis-E prevention trials in Nepal and malaria therapeutic trials in Burma (Myanmar), we address the inadequacies of current ethical guidelines when conducting research within oppressed populations. We review existing legislature in the United States and United Kingdom that may be used against foreign investigators if trial hardships exist. We conclude by making considerations for research conducted within oppressed populations.

Item Type:Article
Uncontrolled Keywords:artesunate; hepatitis E vaccine; hepatitis vaccine; placebo; tenofovir; clinical research; clinical trial; cultural factor; economic aspect; health behavior; hepatitis E; human; Human immunodeficiency virus infection; human rights; law; malaria; medical ethics; Myanmar; Nepal; political system; poverty; practice guideline; priority journal; social aspect; Thailand; United Kingdom; United States; 82864-68-4, 88495-63-0; tenofovir, 147127-19-3, 147127-20-6; Genelabs, Glaxo SmithKline; SmithKline Beecham
Subjects:H Social Sciences > H Social Sciences (General)
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RS Pharmacy and materia medica
Divisions:Faculty > Faculty of Pharmacy
ID Code:1665
Deposited By:INVALID USER
Deposited On:07 May 2010 08:32
Last Modified:06 Jan 2012 16:21
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