The determination of acetaminophen using a carbon nanotube: graphite-based electrode

Moghaddam, A.B. and Mohammadi, A. and Mohammadi, S. and Rayeji, D. and Dinarvand, R. and Baghi, M. and Walker, R.B. (2010) The determination of acetaminophen using a carbon nanotube: graphite-based electrode. Microchimica acta, 171 (3/4). pp. 377-384. ISSN 0026-3672



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The oxidation of acetaminophen was studied at a glassy carbon electrode modified with multi-walled carbon nanotubes and a graphite paste. Cyclic voltammety, differential pulse voltammetry and square wave voltammetry at various pH values, scan rates, and the effect of the ratio of nanotubes to graphite were investigated in order to optimize the parameters for the determination of acetaminophen. Square wave voltammetry is the most appropriate technique in giving a characteristic peak at 0.52 V at pH 5. The porous nanostructure of the electrode improves the surface area which results in an increase in the peak current. The voltammetric response is linear in the range between 75 and 2000 ng.mL−1, with standard deviations between 0.25 and 7.8%, and a limit of detection of 25 ng.mL−1. The method has been successfully applied to the analysis of acetaminophen in tablets and biological fluids.

Item Type:Article
Additional Information:The original publication is available at
Uncontrolled Keywords:Square wave voltammetry ; Multi-walled carbon nanotubes ; Acetaminophen ; Biological fluids ; Pharmaceutical formulation
Subjects:R Medicine > RS Pharmacy and materia medica
Divisions:Faculty > Faculty of Pharmacy
ID Code:1857
Deposited By: Mrs Eileen Shepherd
Deposited On:18 Jan 2011 05:37
Last Modified:06 Jan 2012 16:21
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