Evaluation of the kinetics and mechanism of drug release from Econazole nitrate nanosponge loaded Carbapol Hydrogel

Sharma, R. and Walker, R.B. and Pathak, K. (2011) Evaluation of the kinetics and mechanism of drug release from Econazole nitrate nanosponge loaded Carbapol Hydrogel. Indian Journal of Pharmaceutical Education and Research, 55 (1). pp. 25-31. ISSN 0019-5464

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Abstract

The objective of this study was to investigate the mechanism of release of econazole nitrate (EN) nanosponges loaded hydrogel and to compare it with EN hydrogel so as to develop an extended release topical drug delivery system of EN. Nanosponges of EN were prepared using ethyl cellulose and PVA by emulsion solvent evaporation method. On the basis of pharmacotechnical evaluation nanosponges with least particle size of 230.1 nm and good rheological properties were formulated as hydrogel (F1 – F7). In vitro drug release data of EN nanosponges loaded hydrogels in phosphate buffer pH 6.8 and 7.4 when analysed by GraphPad Prism software version 4.0 San Diego, USA best fitted the Makoid-2 Banakar model (R value greater than 0.98). The Korsmeyer-Peppas release exponent (n) ranged between 0.331 – 0.418, which confirmed diffusion as the principle mechanism of drug release. The release mechanism was further confirmed by calculating the ratio of exponents A/B ratio derived from the Kopcha model.

Item Type:Article
Uncontrolled Keywords:Nanosponge, hydrogel, Makoid-Banakar, Kopcha model, Korsmeyer-Peppas model.
Subjects:R Medicine > RS Pharmacy and materia medica
Divisions:Faculty > Faculty of Pharmacy
ID Code:1879
Deposited By: Mrs Eileen Shepherd
Deposited On:01 Feb 2011 12:10
Last Modified:06 Jan 2012 16:21
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