Analytical methods for the quantitative determination of oxytocin

Chaibva, F. A. and Walker, R.B. (2010) Analytical methods for the quantitative determination of oxytocin. International Journal of Medical and Biological Frontiers , 16 (9-10). pp. 1067-2010. ISSN 1081-3829

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Oxytocin is a clinically important nonapeptide that is used for the induction and/or augmentation of labor and is normally administered as a slow intravenous infusion diluted with normal saline or Ringer’s lactate solution. Oxytocin is also indicated for use in the prevention and treatment of post partum hemorrhage and may be administered via either the intramuscular or intravenous routes in order to increase uterine tone and/or reduce bleeding. The analysis of oxytocin in different media has evolved over the past 30 years with the result that more sophisticated, selective and sensitive techniques are used for the determination of the compound. A variety of techniques have been applied to the determination of oxytocin in different matrices ranging from simple paper chromatography to hyphenated liquid chromatographic such as liquid chromatography coupled with mass-spectrometry. Additionally enzyme linked immuno-sorbent assays (ELISA) and radio immuno-assays (RIA) are used for the determination of low concentrations of oxytocin in biological matrices. This manuscript provides a systematic survey of the analytical methods that have been reported for isolation and quantitation of oxytocin in different matrices.

Item Type:Article
Uncontrolled Keywords:Oxytocin, post partum hemorrhage, paper chromatography, liquid chromatography, mass-spectrometry, enzyme linked immuno-sorbent assays, ELISA, radio immuno-assays, RIA,
Subjects:R Medicine > RS Pharmacy and materia medica
Divisions:Faculty > Faculty of Pharmacy
ID Code:2409
Deposited By: Ms Thandiwe Menze
Deposited On:13 Feb 2012 09:52
Last Modified:01 Aug 2012 07:57
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