Anti-oesophageal cancer activity in extracts of deep-water Marion Island sponges

Davies-Coleman, M.T. and Froneman, P.W. and Keyzers, R.A. and Whibley, C. and Hendricks, D. and Samaal, T. and McQuaid, C.D. (2005) Anti-oesophageal cancer activity in extracts of deep-water Marion Island sponges. South African Journal of Science, 101 (11 & 12). pp. 489-490. ISSN 0038-2353




Oesophageal cancer is one of the most common causes of cancer-related deaths in South African black males. The limited efficacy of chemotherapeutic agents to treat this disease has prompted a search for potential new chemical entities with anticancer properties. We report here on the evidence for anti-oesophageal cancer activity in the methanolic extracts of five species of sponges dredged from a depth of approximately 100 m in the vicinity of Marion Island in the Southern Ocean during the autumn of 2004.

Item Type:Article
Additional Information:Research in Action
Uncontrolled Keywords:natural-products; cytotoxicity; Southern Africa; Southern Ocean; oesophageal cancer; OSCC; oesophageal squamous cell carcinoma; blacks; anticancer; sponges; therapeutic use; Marion Island; marine invertebrates
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Science > Chemistry
Research Institutes and Units > Southern Ocean Group
Faculty > Faculty of Science > Zoology & Entomology
ID Code:350
Deposited By: Mrs Eileen Shepherd
Deposited On:05 Oct 2006
Last Modified:06 Jan 2012 16:17
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