A structural study of the capsular antigen of Klebsiella serotype K43

Aereboe, Michael (1993) A structural study of the capsular antigen of Klebsiella serotype K43. Masters thesis, Rhodes University.

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Abstract

This thesis presents a detailed chemical and spectroscopic determination of the capsular, polysaccharide K-antigen isolated from the Klebsiella bacterium, serotype K43 (culture #2482). The repeating unit of the capsular polysaccharide was found to be of the "3 + 2" repeating unit type. A uronic acid was found as part of a disaccharide side chain and the main chain of the polysaccharide was found to be composed of a neutral trisaccharide of mannose and galactose. The work forms part of an ongoing research interest in bacterial polysaccharides of this laboratory and now completes the structural elucidation of all the Klebsiella K-antigens, bar three antigens which were originally assigned to other laboratories. These data together with the respective serological characteristics of each serotype are available to the molecular biologist, and may result in the production of: vaccine(s) against Klebsiella infections, diagnostic products and novel carrier molecules enabling targeted drug delivery.

Item Type:Thesis (Masters)
Uncontrolled Keywords:Polysaccharide K-antigen, Klebsiella bacterium, Uronic acid, Neutral trisaccharide, Mannose, Galactose, Serological characteristics, Vaccines, Drug delivery
Subjects:R Medicine > RS Pharmacy and materia medica
Divisions:Faculty > Faculty of Pharmacy
Supervisors:Parolis, H.
ID Code:4132
Deposited By: Philip Clarke
Deposited On:26 Nov 2012 12:13
Last Modified:26 Nov 2012 12:13
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