Structural studies on the capsular antigens of Escherichia coli serotypes K102 and K47

De Bruin, Aletta Hester (1992) Structural studies on the capsular antigens of Escherichia coli serotypes K102 and K47. Masters thesis, Rhodes University.

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Abstract

The work presented in this thesis forms part of a continuing programme concerned with the structural determination of capsular polysaccharides of some Enterobacteriaceae. Since bacteria of this family are pathogenic to Man, work in this laboratory has focused on the structural elucidation of Klebsiella and, more recently, Escherichia coli ( E. coli) capsular polysaccharides ( K-antigens ). To date, some 74 K-antigens have been distinguished serologically within the genus E. coli and the structures of approximately 70% are known. In general, the K-antigens of the E. coli are characterized by a wide variety of constituent monosaccharides arranged in repeating units. In this thesis the structural elucidation of the capsular polysaccharides of E. coli serotypes 08: KI02: H- and 08: K47: H2 is presented. A variety of chemical techniques has been employed in the structural analysis, and are discussed. The thesis also includes extensive two-dimensional n.m.r. studies on the E. coli KI02 and K47 polysaccharides, as well as on a modified KI02 polymer produced after a lithium-ethylenediamine degradation of the native polysaccharide.

Item Type:Thesis (Masters)
Uncontrolled Keywords:Structure, Capsular polysaccharides, Enterobacteriaceae, Klebsiella, Escherichia coli, K-antigens
Subjects:R Medicine > RS Pharmacy and materia medica
Divisions:Faculty > Faculty of Pharmacy
Supervisors:Parolis, H.
ID Code:4140
Deposited By: Philip Clarke
Deposited On:26 Nov 2012 12:25
Last Modified:26 Nov 2012 12:25
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