Bioavailability and activity of 0.1% amcinonide preparations: comparison with proprietary topical corticosteroid formulations of differing potencies

Woodford, R. and Haigh, J.M. (1979) Bioavailability and activity of 0.1% amcinonide preparations: comparison with proprietary topical corticosteroid formulations of differing potencies. Current Therapeutic Research, 26 (3). pp. 301-310. ISSN 0011-393X

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Abstract

The activity of a 0.1% amcinonide cream was compared with those of selected proprietary topical corticosteroid formulations of potencies differing according to the United Kingdom (U.K.) MIMS classification (very potent, potent and moderately potent) using a standard six hour vasoconstrictor assay with multiple reading times. Statistical analysis indicated that 0.1% amcinonide cream feU within the category of a very potent preparation. Three 0.1% amcinonide formulations (cream, combination cream and combination ointment, the last two containing anti-infective agents) were equipotent in the skin-blanching test.

Item Type:Article
Uncontrolled Keywords:amcinonide; betamethasone; clobetasol propionate; corticosteroid; diflucortolone valerate; fluocinolone acetonide; fluocinonide; halcinonide; bioavailability; skin vasoconstriction; ultradil; vasoconstriction
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:593
Deposited By: Prof John Haigh
Deposited On:05 Jun 2007
Last Modified:06 Jan 2012 16:18
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