The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream

Magnus, A.D. and Haigh, J.M. and Kanfer, I. (1981) The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream. Dermatologica, 163 . pp. 331-337. ISSN 0011-9075

[img]
Preview
Text
Pub25.pdf

1929Kb

Abstract

Six different vehicles for topical use were used to prepare 50% dilutions of Betnovate@ (betamethasone 17-valerate, 0.1 %) cream. Blanching assessment was undertaken immediately after preparing the various dilutions and at 1 and 3 months thereafter. Few statistically significant differences were noted between any of the preparations tested indicating that the rate of release of betamethasone 17-valerate is relatively unaffected by dilution. All preparations were assayed by a stability indicating high pressure liquid chromatographic technique for corticosteroid content. A diminution in the content of betamethasone 17-valerate in the E45 dilution was found 14 months after preparation. All other formulations tested were found to comply with label claim specifications.

Item Type:Article
Uncontrolled Keywords:blanching activity; opical corticosteroid; Betamethasone 17-valerate; extemporaneous dilutions
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:595
Deposited By: Prof John Haigh
Deposited On:05 Jun 2007
Last Modified:06 Jan 2012 16:18
1582 full-text download(s) since 05 Jun 2007
284 full-text download(s) in the past 12 months
More statistics...

Repository Staff Only: item control page