Tools
Tools
Gochin, R. and Kanfer, I. and Haigh, J.M. (1981) The simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetylsulphamethoxazole in biological fluids by high pressure liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 223 (1). pp. 139-145. ISSN 1570-0232
|
Text
Pub26.pdf 2551Kb |
Official URL: http://dx.doi.org/10.1016/S0378-4347(00)80076-6
Abstract
The simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetylsulphamethoxazole in serum and urine by high-performance liquid chromatography using sulphafurazole as internal standard is described. The separation was achieved on a reversed-phase column employing acetic acid-methanol as the mobile phase with spectrophotometric detection at 230 nm. Precise simultaneous quantitative analysis of the relative components has been achieved at levels of 0.1 μg/ml for both sulphamethoxazole and its N4-acetyl metabolite using 1 ml of serum or urine.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | n4 acetylsulfamethoxazole; sulfamethoxazole; trimethoprim; acetylsulfamethoxazole; drug determination; drug mixture; high performance liquid chromatography; human; serum; urine |
| Subjects: | Y Unknown > Subjects to be assigned |
| Divisions: | Faculty > Faculty of Pharmacy |
| ID Code: | 596 |
| Deposited By: | Prof John Haigh |
| Deposited On: | 31 May 2007 |
| Last Modified: | 06 Jan 2012 16:18 |
97 full-text download(s) in the past 12 months
More statistics...
Repository Staff Only: item control page