In vitro-in vivo evaluation of a sustained release phenylpropanolamine oral dosage form

Dowse, R. and Haigh, J.M. and Kanfer, I. (1982) In vitro-in vivo evaluation of a sustained release phenylpropanolamine oral dosage form. South African Pharmaceutical Journal, 49 . pp. 485-487. ISSN 0038-2258

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Abstract

There is increasing interest in measuring pharmacokinetic parameters of phenylpropanolamine (PPA), a sympathomimetic amine used in over-the-counter nasal decongestants and anorectic formulations. A high pressure liquid chromatographic (HPLC) procedure was developed to enable direct ultraviolet detection of PPA, after extraction from serum and urine, without prior derivatization of the drug. This method was used to assay samples obtained from a bioavailability study of BUBtained-releasePPA tablets. The mean serum and urine profiles obtained are presented. The sustained-release tablets were subjected to dissolution testing utilizing the United States Pharmacopoeia (USP XIX) rotating basket method. An internal standard was incorporated into the dissolution fluid to enable direct analysis of the samples by HPLC. A comparison of three different dissolution fluid regimens was carried out to determine if release of the drug was affected by the change in pH of the medium and to select the most convenient method for the final dissolution studies. Some preliminary observations relating to correlations between rate of drug release from the sustained-release dosage form and percent drug absorbed are presented.

Item Type:Article
Uncontrolled Keywords:in vivo/in vitro evaluation; sustained release; phenylpropanolamine; oral dosage
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:600
Deposited By: Prof John Haigh
Deposited On:05 Jun 2007
Last Modified:06 Jan 2012 16:18
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