Possible dosage regimens for topical steroids assessed by vasoconstrictor assays using multiple applications

Woodford, R. and Haigh, J.M. and Barry, B.W. (1983) Possible dosage regimens for topical steroids assessed by vasoconstrictor assays using multiple applications. Dermatologica, 166 (3). pp. 136-140. ISSN 0011-9075

[img]
Preview
Text
Pub31.pdf

1700Kb

Abstract

The bioavailabilities and activities of three amcinonide preparations and Betnovate cream were assessed using three multiple-dosage regimen vasoconstrictor assays in 10 volunteers. Applications were made once daily, twice daily and every alternate day with an initial three times daily loading dose applied on the first day only. Blanching responses first increased and then decreased due to tachyphylaxis. It is proposed that clinically the most advantageous dosage regimen is a once daily application with no loading dose.

Item Type:Article
Uncontrolled Keywords:topical steroids; bioavailability and activity; cortocosteroids; vasocontrictor; Amcinonide; dosage regimens
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:601
Deposited By: Prof John Haigh
Deposited On:05 Jun 2007
Last Modified:06 Jan 2012 16:18
813 full-text download(s) since 05 Jun 2007
173 full-text download(s) in the past 12 months
More statistics...

Repository Staff Only: item control page