Phenylpropanolamine hydrochloride

Kanfer, I. and Haigh, J.M. and Dowse, R. (1983) Phenylpropanolamine hydrochloride. Analytical Profiles of Drug Substances, 12 . pp. 357-383. ISSN 0099-5428

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Abstract

Phenylpropanolamine hydrochloride belongs to the sympathomimetic amine class of drugs and is structurally related to ephedrine hydrochloride. Its synthesis was first reported in 1910 (1) and the first 1\mericanpatent was registered in 1939. The effects of phenylpropanolamine hydrochloride are largely the result of alpha-adrenergic agonist activity resulting from both direct stimulation of adrenergic receptors and release of neuronal norepinephrine. The principal adverse effect of phenylpropanolamine hydrochloride is d9se-related hypertension and ventricular arrhythmia has been'described (2). Phenylpropanolamine hydrochloride is widely used as a decongestant and it has been used as an anorectic agent for over 40 years (3). A report in 1939 (4) described its effect as an hypertensive agent when administered parenterally.

Item Type:Article
Additional Information:This profile attempts to cover the published literature on phenylpropanolamine hydrochloride up to July 1982.
Uncontrolled Keywords:Phenylpropanolamine hydrochloride
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:603
Deposited By: Prof John Haigh
Deposited On:05 Jun 2007
Last Modified:06 Jan 2012 16:18
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