Comparative bioavailability of some locally manufactured betamethasone valerate containing preparations

Meyer, E. and Haigh, J.M. and Kanfer, I. (1983) Comparative bioavailability of some locally manufactured betamethasone valerate containing preparations. South African Pharmaceutical Journal, 50 . pp. 443-447. ISSN 0038-2558

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Abstract

The bioavailabilities of three locally manufactured proprietary betamethasone- 17-valerate containing creams and ointments were compared by measuring their abilities to cause blanching of human skin after topical application. The preparations studied were Betnovate Cream and Ointment, Celestoderm-V Cream and Ointment and Persivate Cream and Ointment. Celestoderm-V cream displayed a significantly superior blanching activity over both Betnovate and Persivate creams in' the occluded mode, whereas Persivate cream displayed a significantly superior blanching activity over both Betnovate and Celestoderm-V creams in the unoccluded mode. Persivate ointment was found to produce a significantly superior blanching activity over Betnovate and Celestoderm-V ointments in both the occluded and unoccluded modes of application.

Item Type:Article
Uncontrolled Keywords:betamethasone valerate; topical preparations; bioavailability; comparisons
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:604
Deposited By: Prof John Haigh
Deposited On:05 Jun 2007
Last Modified:06 Jan 2012 16:18
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