Determination of erythromycin in serum and urine by high performance liquid chromatography with ultraviolet detection

Stubbs, C. and Haigh, J.M. and Kanfer, I. (1985) Determination of erythromycin in serum and urine by high performance liquid chromatography with ultraviolet detection. Journal of Pharmaceutical Sciences, 74 (10). pp. 1126-1128. ISSN 0022-3549

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Official URL: http://dx.doi.org/10.1002/jps.2600741027

Abstract

A high-performance liquid chromatographic analysis of erythromycin in human serum and urine with UV detection at 200 nm is presented. The method involves a solid-phase extraction procedure followed by a simple phase separation step and chromatography on a reversed-phase column. The method has sensitivity limits of 0.25 and 1.0 g/mL in serum and urine, respectively, and is sufficiently sensitive to monitor concentrations of erythromycin in human serum and urine after the administration of a single 500-mg erythromycin stearate tablet.

Item Type:Article
Uncontrolled Keywords:erythromycin; drug determination; drug monitoring; drug urine level; erythrocin
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:607
Deposited By: Prof John Haigh
Deposited On:05 Jun 2007
Last Modified:06 Jan 2012 16:18
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