Pharmacokinetics of phenylpropanolamine in humans after a single dose study

Dowse, R. and Haigh, J.M. and Kanfer, I. (1987) Pharmacokinetics of phenylpropanolamine in humans after a single dose study. International Journal of Pharmaceutics, 39 (1/2). pp. 141-148. ISSN 0378-5173

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Official URL: http://dx.doi.org/10.1016/0378-5173(87)90209-2

Abstract

The pharmacokinetics of phenylpropanolamine have been studied in healthy human volunteers following the oral administration of an aqueous solution of the drug (50 mg/200 ml). Blood and urine samples collected throughout the trial were assayed using HPLC with UV detection. The drug was shown to be rapidly absorbed with a mean tmax of 1.47 ± 0.49 h and a mean elimination half-life of 4.0 ± 0.5 h. Phenylpropanolamine is predominantly excreted via the kidney with a mean renal clearance of 0.646 ± 0.089 liter/kg/h and 90.2 ± 1.7% excreted unchanged in the urine. The data were not well described using conventional one or two body compartment models. However, the incorporation of a discontinuous absorption phase into the models resulted in an improved overall fit with better characterisation of the absorption phase.

Item Type:Article
Uncontrolled Keywords:phenylpropanolamine; 14838-15-4; 154-41-6; 4345-16-8; 48115-38-4
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:617
Deposited By: Prof John Haigh
Deposited On:31 May 2007
Last Modified:06 Jan 2012 16:18
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