A stability-indicating liquid chromatographic method for the analysis of erythromycin in stored biological fluids using amperometric detection

Stubbs, C. and Haigh, J.M. and Kanfer, I. (1987) A stability-indicating liquid chromatographic method for the analysis of erythromycin in stored biological fluids using amperometric detection. Journal of Liquid Chromatography, 10 (11). pp. 2547-2557. ISSN 0148-3919

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Official URL: http://dx.doi.org/10.1080/01483918708068934

Abstract

A simple, sensitive and reliable high-performance liquid chromatographic procedure has been developed for the determination of erythromycin in human serum and urine using amperometric detection. A solid-phase extraction procedure was used followed by chromatography on a reverse-phase column. The mean recovery of erythromycin from serum and urine was 80%. This method allows both erythromycin and its principle degradation product, anhydroeythromycin, to be determined during a period of sample storage at 4 degree C and minus 15 degree C. The method is sufficiently sensitive and precise and is thus highly suited for use in both pharmacokinetic and stability studies.

Item Type:Article
Uncontrolled Keywords:AMPEROMETRIC DETECTION; ANHYDROERYTHROMYCIN; BIOLOGICAL FLUIDS; ERYTHROMYCIN
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:618
Deposited By: Prof John Haigh
Deposited On:01 Jun 2007
Last Modified:06 Jan 2012 16:18
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