The human skin-blanching assay for comparing topical corticosteroid availability

Smith, E.W. and Meyer, E. and Haigh, J.M. and Maibach, H.I. (1991) The human skin-blanching assay for comparing topical corticosteroid availability. Journal of Dermatological Treatment, 2 . pp. 69-72. ISSN 0954-6634

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Abstract

The human skin blanching assay remains in widespread use as a reliable, qualitative, comparative indicator of topical corticosteroid availability and potency. The experimental refinements promulgated by certain researchers in this field have yielded a versatile bioassay for the accurate assessment of new drugs or delivery vehicles. With the increasing appearance of generic topical corticosteroid formulations which compete with trade-name equivalents, the vital importance of this assay in regulatory affairs and assessing bioequivalence has been re-emphasized. It is stressed that if the blanching assay is to be used in this sphere, then multiple-reading trials must be conducted; important registration or clinical decisions cannot be made with any validity from short-term assessments. (J Dermatol Treat (1991) 2: 69-72)

Item Type:Article
Uncontrolled Keywords:Blanching ; Skin ; Investigation method ; Pharmacokinetics ; Human ; Bioavailability ; Corticosteroid ; Local administration ; Topical administration
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:625
Deposited By: Prof John Haigh
Deposited On:31 May 2007
Last Modified:06 Jan 2012 16:18
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