The use of supersaturated solutions for the percutaneous delivery of rooperol tetra-acetate

Pefile, S.C. and Haigh, J.M. and Smith, E.W. (1998) The use of supersaturated solutions for the percutaneous delivery of rooperol tetra-acetate. In: Proceedings of the 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. Association de pharmacie galénique industrielle (France), Châtenay-Malabry, France, pp. 843-844.

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Abstract

A major problem encountered in the transdennal delivery of drugs is the effectiveness of the barrier system imposedby the stratum corneum.To overcome tbe resistance of the skin to the ingress of exogenous chemicals, numerous innovative techniques requiring complex delivery systems have been studied. Many of these systems attempt to alter the barrier potential by the use of enhancer technology. Supersaturation, on the other hand, is a simple and economical technique which is not intended to modify the physical structure or the chemical compositionof the stratum corneum, yet may effectively deliver a markedly greater mass of drug to the skin than that achieved by the use of conventional, saturated solutions. Supersaturated systemsmake use of the elevated thermodynamic activity of the permeant in the deliveryvehicle, which results in higher flux rates across the contacting membrane by increasing the concentration gradient. The present study investigated the potential for using supersaturation techniques to transdermally deliver rooperol tetraacetate (RTA), a lipophilic, cytotoxic agent with potential for use in the treatment of solar keratosis. The diffusion characteristics of the drug from a 60% propylene glycol/water supersaturated solution across silicone membrane and full thickness rat skin were studied using Franz diffusion cells. A comparison was made of the drug diffusion rates from a saturated system and from supersaturated systems prepared with and without an antinucleating agent.

Item Type:Book Section
Uncontrolled Keywords:transdermal delivery; drugs; RTA; rooperol tetra-acetate
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:635
Deposited By: Prof John Haigh
Deposited On:31 May 2007
Last Modified:06 Jan 2012 16:18
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