The effects of buffer molarity, agitation rate and mesh size on verapamil release from modified release mini-tablets using USP Apparatus 3

Khamanga, S.M.M. and Walker, R.B. (2007) The effects of buffer molarity, agitation rate and mesh size on verapamil release from modified release mini-tablets using USP Apparatus 3. Dissolution Technologies, 14 (2). pp. 19-23. ISSN 1521-298X

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Abstract

The effects of agitation rate, buffer molarity,and mesh size on the dissolution rate of verapamil hydrochloride from sustained release matrix tablets were studied using USP Apparatus 3. Eudragit® and Carbopol® were used as rate-retarding polymers in tablets prepared by wet granulation.The study was conducted to determine whether the drugs exhibit similar release characteristics when tested under the same dissolution conditions. It was found that the dissolution rate of verapamil hydrochloride was affected by the variables assessed in these studies.

Item Type:Article
Uncontrolled Keywords:dissolution; USP Apparatus 3; modified release; verapamil
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
ID Code:735
Deposited By: Prof Rod Walker
Deposited On:06 Dec 2007
Last Modified:06 Jan 2012 16:18
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