Analysis of macrolide antibiotics

Kanfer, I. and Skinner, M.F. and Walker, R.B. (1998) Analysis of macrolide antibiotics. Journal of Chromatography A, 812 (1/2). pp. 255-286. ISSN 0021-9673

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Official URL: http://dx.doi.org/10.1016/S0021-9673(98)00276-3

Abstract

The following macrolide antibiotics have been covered in this review: erythromycin and its related substances, azithromycin, clarithromycin, dirithromycin, roxithromycin, flurithromycin, josamycin, rokitamycin, kitasamycin, mycinamycin, mirosamycin, oleandomycin, rosaramicin, spiramycin and tylosin. The application of various thin-layer chromatography, paper chromatography, gas chromatography, high-performance liquid chromatography and capillary zone electrophoresis procedures for their analysis are described. These techniques have been applied to the separation and quantitative analysis of the macrolides in fermentation media, purity assessment of raw materials, assay of pharmaceutical dosage forms and the measurement of clinically useful macrolide antibiotics in biological samples such as blood, plasma, serum, urine and tissues. Data relating to the chromatographic behaviour of some macrolide antibiotics as well as the various detection methods used, such as bioautography, UV spectrophotometry, fluorometry, electrochemical detection, chemiluminescence and mass spectrometry techniques are also included.

Item Type:Article
Uncontrolled Keywords:Antibiotics; Macrolides; Erythromycins; pharmaceutical analysis; chromatography; drug determination
Subjects:Y Unknown > Subjects to be assigned
Divisions:Faculty > Faculty of Pharmacy
Research Institutes and Units > Biopharmaceutics Research Unit
ID Code:776
Deposited By: Mrs Eileen Shepherd
Deposited On:14 Aug 2007
Last Modified:06 Jan 2012 16:19
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